Prof. Onno Kranenburg

Prof. Onno Kranenburg

Professor of Surgical and Translational Tumor Biology, Cancer Center UMC Utrecht

Onno Kranenburg is Professor Translational Tumor Biology at the University Medical Center Utrecht (UMCU) and heads the Lab Translational Oncology.

He is also a member of the daily board of the focus area Cancer at the UMCU, coordinator of the PhD education program Clinical and Translational Oncology, and chair of the Utrecht Platform for Organoid Technology (U-PORT).

U-PORT supports the application and further development of organoid technology. Organoids provide excellent model systems for studying all the hallmarks of cancer, including cancer metastasis.

Using colorectal cancer organoids, Kranenburg studies multiple aspects of CRC metastasis, including mechanisms of organ-specific dissemination, survival and outgrowth.

New insights in CRC metastasis biology are used to develop novel diagnostic tools and treatment strategies. These are tested in organoid-based mouse models and, ultimately, in clinical studies.

 

ABSTRACT

Title: Organoid-based models for metastatic Colorectal Cancer with high microsatellite instability 

Summary: Colorectal Cancers (CRC) with a deficient mismatch repair system (dMMR) are characterized by a high level of microsatellite instability (MSI-H) and a hyper-mutated genome. MSI-H is associated with a relatively good prognosis in primary CRC, but with poor prognosis in metastatic CRC (mCRC).

The immunogenic nature of MSI-H mCRC tumors underlies their unique responsiveness to immune-checkpoint inhibitors (ICIs), but response rates are highly variable. Model systems for further pre-clinical optimization of the treatment of MSI-H mCRC are currently lacking.

We describe the establishment of organoids from MSI-H mCRC tumors and organoid-initiated metastasis models, using immune-deficient and Human Immune System (HIS) mice.

The results demonstrate that organoids from MSI-H mCRC can be used for building spontaneous metastasis models in mice involving all relevant distant sites, and in the context of a human immune system. This allows for evaluation of ICI therapies and for further improving ICI-based therapeutic strategies.

IACR Membership

We have a number of membership categories available. Find out which membership suits you.

IACR Conference

Due to COVID restrictions we have yet to confirm the dates for 57th Annual Conference. 

Please check back here later in 2020 to check for updates. 

IACR Public Engagement

Would you like to know more about how we involve patients in research, our fundraising, and lay seminars?

Contact Us

1 + 14 =

Latest News

Education Grants

The Irish Association for Cancer Research will support a limited number of Educational Grants that
will be made available to postgraduate PhD researchers who have been affected by the Covid-19
pandemic. We acknowledge that many of our members have been significantly impacted by the
recent pandemic that may have affected their ability to continue and/or complete research projects.

FACEBOOK

Irish Association
for Cancer Research  

9A Coolkill, Sandyford
Dublin 18, Ireland
D18 C1W3

info@iacr.ie
+353 (0)295 8859

Irish Association for Cancer Research (IACR) is a registered charity on the Register of Charitable Organisations, Charities Regulator, 3 George's Dock, IFSC, Dublin 1, D01 X5X0, Ireland.

Registered Charity Number (RCN): 20030117.

©Design by LetterEleven