Prof. Samuel Janes
Head of the Respiratory Research Department at UCL, and Vice-Dean Research for the Faculty of Medical Sciences
Sam won an MRC Training Fellowship to perform a PhD and then a post-doctoral period working in the CRUK Lincoln’s Inn Fields Institute with Fiona Watt working on stem cell biology. He then moved as an MRC Clinician Scientist to UCL leading a group interested in the role of stem cells in lung cancer pathogenesis and treatment of lung disease using cell therapies. He was awarded a Wellcome Trust Senior Clinical Fellowship in October 2010 to work on novel cell therapies for lung cancers resulting in a DPFS first-in-man award and in 2015 won his Wellcome Senior Fellowship renewal to study the genetic and cellular changes lung cancer pathogenesis. He is the lead of four academic randomised clinical trials and most notably recently recruited 13,000 people to the SUMMIT study, a London based study examining CT and blood screening for lung and other cancers.
He works as a respiratory consultant at UCLH with a particular interest in lung cancer, mesothelioma, interventional and diagnostic bronchoscopy and early lung cancer detection. He is Head of Respiratory Research Department at UCL, Vice-Chair of the National ‘Clinical Expert Group’ on Lung Cancer and Vice-Dean of Research at UCL.
3D mammosphere culture of breast epithelial cell line MCF10A.
Courtesy of Dr. Emer Bourke, NUI Galway
Phospho-Akt expression and localisation
Mediated by VEGF in A549 lung cancer cells. Visualised by high content image analysis.
Metaphase chromosome spread of Jurkat T-lymphoma cells
Apoptosis assessment of SKMES-1 lung cancer cells
Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).
Mitotic Chronic Myelogenous Leukaemia K562 Cells
Cell to Cell Tweeting
Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC)
Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.
Confocal Microscopy Analysis
Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).
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