
Prof Rosemary O'Connor
UCC
Rosemary O’Connor is Professor of Cell Biology and Head of the School of
Research experience was gained in Germany and the USA in academia (at the Institute of Pathology of the University of Wurzburg and the Wistar Institute at U
She joined the Department of Biochemistry in UCC in 1997 and established a research programme in cancer biology and also the establishment of structured
She holds
She was awarded the Irish Area Medal by the Biochemical Society in 2007 and serves on a number of international scientific and funding bodies.
Abstract:
Unsolved Mysteries – Insulin and IGF activity in Cancer
It is well known from genetic studies and simple animal models that the Insulin/IGF system protects cells and tissues and prevents diseases of
High levels of Insulin/IGF signaling, which can arise due to lifestyle, environmental factors, or certain diseases/conditions can facilitate the onset and progression of cancer, and shorten lifespan. In mice, pharmacological suppression of IGF activity has the same effects as
However, pharmacological intervention in the IGF signaling pathway in humans has proven difficult, as demonstrated by the lack of success of multiple kinase inhibitors and antibodies in
This talk will explore some of the unsolved mysteries and our approaches to addressing them. These include what distinguishes Insulin and IGF actions, why protection of mitochondria and mitochondrial dysfunction is important, and how this pathway can be hijacked in cancer cells.
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Latest News
PhD in Tumour Immunology
A fully funded 4-year PhD studentship (€18,000 per annum stipend) is available in the research group of Dr. Aideen Ryan.
Education Grant 2020
The Irish Association for Cancer Research supported five Educational Grants in 2020. These were made available to postgraduate PhD researchers who had been affected by the Covid-19 pandemic.

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