Prof Manuel Salto Tellez
Professor Manuel Salto-Tellez (MD-LMS, FRCPath, FRCPI) is the Chair of Molecular Pathology at Queen’s University
By January 2019, Prof Salto-Tellez was
He studied Medicine in Spain (Oviedo), Germany (Aachen) and The Netherlands (Leiden). He specialized in Histopathology in the UK (Edinburgh and London) and in Molecular Pathology in
Prof Salto-Tellez serves in committees associated with CRUK, NICE
Histopathology became an established, global and accepted clinical discipline in the first half of the 20th Century. Since then 3 main developments have reshaped the way we practice it.
Immunohistochemistry (IHC)  provided important information in both diagnostic and discovery, helping the delivery of a more accurate and sophisticated taxonomy of diseases (diagnostic value), and also the performance of key tests with a genetic, prognostic and predictive value . The second revolution (“the molecular diagnostic revolution”) was different and, in many occasions, this analysis has been performed outside the routine pathological strategies, making pathologists facilitators rather
In our opinion, Digital Pathology (DP) and Artificial Intelligence (AI) represents an incipient “third revolution” that is strongly knocking at the door of pathology. From a practical point of view, DP/AI have the potential to make the complex and fragmented pathway of routine pathological tissue interrogation a more seamless
This lecture will discuss in detail our contributions to the application of DP in
1. Soilleux E and Gatter KC. The Antibody Revolution: How ‘Immuno’ Changed Pathology. Chapter 15 in Understanding Disease: A Centenary Celebration of the Pathological Society, 2006, Hall P and Wright NA editors, John Wiley & Sons, Incorporated, ISBN-10 0470032200 & ISBN-13 9780470032206
2. McCourt CM, Boyle D, James J, Salto-Tellez M. Immunohistochemistry in the era of
3. Morphomolecular pathology: setting the framework for a new generation of pathologists. Jones JL, Oien KA, Lee JL, Salto-Tellez M. Br J Cancer. 2017 Nov 21;117(11):1581-1582.
4. Time for change: a new training programme for morpho-molecular pathologists? Moore DA, Young CA, Morris HT, Oien KA, Lee JL, Jones JL, Salto-Tellez M. J Clin Pathol. 2018 Apr;71(4):285-290.
5. Integrated tumor identification and automated scoring minimizes pathologist involvement and provides new insights to key biomarkers in breast cancer. Bankhead P, Fernández JA, McArt DG, Boyle DP, Li G, Loughrey MB, Irwin
3D mammosphere culture of breast epithelial cell line MCF10A.
Courtesy of Dr. Emer Bourke, NUI Galway
Phospho-Akt expression and localisation
Mediated by VEGF in A549 lung cancer cells. Visualised by high content image analysis.
Metaphase chromosome spread of Jurkat T-lymphoma cells
Apoptosis assessment of SKMES-1 lung cancer cells
Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).
Mitotic Chronic Myelogenous Leukaemia K562 Cells
Cell to Cell Tweeting
Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC)
Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.
Confocal Microscopy Analysis
Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).
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