Prof. Hellmut G. Augustin
Retired Producer and Presenter RTÉ
Hellmut G. Augustin is Professor of Vascular Biology at the Medical Faculty Mannheim of Heidelberg University, Head of the Division for Vascular Oncology and Metastasis Research at the German Cancer Research Center (DKFZ), and Founding Director of the European Center for Angioscience at Heidelberg University, Germany. Trained as a Veterinary Pathologist (Hannover, Germany) and as PhD in Experimental Pathology (Cornell University, USA), he worked previously as Assistant Professor at the University of Göttingen, Germany and as Department Head at the Tumor Biology Center in Freiburg, Germany. He is the Speaker of the Collaborative Research Center “Vascular Control of Organ Function” (www.sfb1366.de) and Chairman of VWFB e.V. (www.vwfb.de), host of the Kloster Seeon Meetings on Angiogenesis.
The Augustin lab (www.augustinlab.de) studies angiocrine signaling mechanisms and organotypic vascular functional differentiation during the life cycle of a vasculature (blood vessel formation, assembly, maturation, quiescence, regression, aging) with a particular focus on tumor-vessel interactions that govern tumor progression and metastasis. Basic discovery research feeds translational research with the goal of identifying and validating novel therapeutic targets as well as laying the preclinical proof-of-concept for novel treatment modalities and therapeutic windows, including neoadjuvant and adjuvant therapy.
3D mammosphere culture of breast epithelial cell line MCF10A.
Courtesy of Dr. Emer Bourke, NUI Galway
Phospho-Akt expression and localisation
Mediated by VEGF in A549 lung cancer cells. Visualised by high content image analysis.
Metaphase chromosome spread of Jurkat T-lymphoma cells
Apoptosis assessment of SKMES-1 lung cancer cells
Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).
Mitotic Chronic Myelogenous Leukaemia K562 Cells
Cell to Cell Tweeting
Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC)
Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.
Confocal Microscopy Analysis
Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).
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