Prof Doreen Cantrell PhD, FRSE, FRS, CBE

Prof Doreen Cantrell PhD, FRSE, FRS, CBE

Dundee

Professor Doreen Cantrell is a Wellcome Trust Principal Research Fellow at the School of Life Sciences, University of Dundee. Her research interests are focused on T lymphocyte development and activation, a key process to the comprehension and manipulation of mammalian immune responses. She has published over 180 research papers and was elected a Fellow of the Academy of Medical Sciences and EMBO in 2000, a Fellow of the Royal Society of Edinburgh in 2005 and a Fellow of the Royal Society in 2011. She was awarded Commander of the British Empire in the 2014 New Year Honours for her services to the UK Science.

Abstract:
ENVIRONMENT CONTROL OF T CELL FUNCTION

Prof Doreen Cantrell, Professor of Cellular Immunology and Wellcome Trust Principal Research Fellow, School of Life Sciences, University of Dundee, Dundee

The T lymphocyte response to pathogens is shaped by the T cell microenvironment and key environmental signals are provided by amino acids, glucose and oxygen. Environmental sensors in T cells include the nutrient-sensing serine/threonine kinases, adenosine monophosphate-activated protein kinase and mammalian target of rapamycin complex 1 and signaling pathways regulated by intracellular protein O-GlcNAcylation. Other environmental sensors are transcription factors such as c-myc, hypoxia-inducible factor-1 and the aryl hydrocarbon receptor. The present talk will explore the molecular basis for the impact of environmental signals on the differentiation of conventional T cell receptor αβ T cells and how the T cell response to immune stimuli can coordinate the T cell response to environmental cues.

3D mammosphere culture of breast epithelial cell line MCF10A.

Courtesy of Dr. Emer Bourke, NUI Galway

Phospho-Akt expression and localisation

Mediated by VEGF in A549 lung cancer cells. Visualised by high content image analysis.

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

Metaphase chromosome spread of Jurkat T-lymphoma cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Apoptosis assessment of SKMES-1 lung cancer cells

Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

HeLa Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

IACR & EACR Joint Conference 2020

26 — 28 February 2020 at Galway Bay Hotel, Galway

Mitotic Chronic Myelogenous Leukaemia K562 Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Cell to Cell Tweeting

Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC)

Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.

Confocal Microscopy Analysis

Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

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