Dr David Finlay, PhD, F.T.C.D

Dr David Finlay, PhD, F.T.C.D

TCD

Dr David Finlay is an Associate Professor in Immunometabolism in the School of Biochemistry and Immunology and the School of Pharmacy and Pharmaceutical Sciences at Trinity College Dublin. He graduated with a bachelor’s degree in Biochemistry from Trinity College Dublin in 2001 and a PhD in Biochemistry from the University of Dundee in 2006. He completed his postdoctoral trained in the lab of Prof. Doreen Cantrell at the University of Dundee before starting his independent research group in Trinity College Dublin in 2012. Dr Finlay’s research is at the forefront of the emerging field of Immunometabolism. His research team are revealing novel strategies to modulate immune cell function through targeting cellular metabolism and new therapeutic opportunities are being explored. Dr Finlay’s research has been published in the top journals in the field of Immunology and he is the recipient of major awards including a Science Foundation Ireland Career Development Award in 2014 and a European Research Council Consolidator Award in 2017.

Short Abstract
For robust anti-tumour functions NK cells increase the uptake of cellular fuels and the flux through metabolic pathways. We have characterised these metabolic responses in activated NK cells, discovered the metabolic regulators involved and their importance for NK cell effector function. NK cells have profound metabolic defects in various disease states where NK cell functional responses are impaired. These discoveries have important implications for NK cell immunotherapies.

3D mammosphere culture of breast epithelial cell line MCF10A.

Courtesy of Dr. Emer Bourke, NUI Galway

Phospho-Akt expression and localisation

Mediated by VEGF in A549 lung cancer cells. Visualised by high content image analysis.

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

Metaphase chromosome spread of Jurkat T-lymphoma cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Apoptosis assessment of SKMES-1 lung cancer cells

Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

HeLa Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

IACR & EACR Joint Conference 2020

26 — 28 February 2020 at Galway Bay Hotel, Galway

Mitotic Chronic Myelogenous Leukaemia K562 Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Cell to Cell Tweeting

Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC)

Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.

Confocal Microscopy Analysis

Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

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Education Grant 2020

The Irish Association for Cancer Research supported five Educational Grants in 2020. These were made available to postgraduate PhD researchers who had been affected by the Covid-19
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