Prof. Corrado Santocanale

NUIG

Centre for Chromosome Biology at National University of Ireland Galway

Research Focus
We are combining proteomics, gene editing and chemical genetic approaches to identify new CDC7 substrates and interacting proteins. Their characterization will increase our knowledge of the physiological processes in which the kinase is involved and how its activity is regulated.

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Chromosome Biology

3D mammosphere culture of breast epithelial cell line MCF10A.

Courtesy of Dr. Emer Bourke, NUI Galway

Phospho-Akt expression and localisation

Mediated by VEGF in A549 lung cancer cells. Visualised by high content image analysis.

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

Metaphase chromosome spread of Jurkat T-lymphoma cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Apoptosis assessment of SKMES-1 lung cancer cells

Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

HeLa Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

IACR & EACR Joint Conference 2020

26 — 28 February 2020 at Galway Bay Hotel, Galway

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Mitotic Chronic Myelogenous Leukaemia K562 Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Cell to Cell Tweeting

Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC)

Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.

Confocal Microscopy Analysis

Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

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