Prof. Bernard Thienpont

Prof. Bernard Thienpont

Laboratory for Functional Epigenetics, Department of Human Genetics, KU Leuven, Belgium

Prof. Bernard Thienpont has a multidisciplinary background in both bio-engineering and Genetics. He continually strives to bridge clinical and basic research. During his PhD he was trained in cardiovascular genomics, developing novel analysis methods to identify cryptic chromosomal aberrations in children born with heart defects. He next moved to Cambridge, UK to work on the epigenomics of cardiovascular diseases, aiming to understand how pathologically hypertrophied hearts re-express their fetal gene programme.  During subsequent work at the VIB Center for Cancer Biology, he studied how hypoxia interacts with DNA methylation in tumors, and how these changes impact the hypoxia response. We showed that tumour hypoxia impedes demethylation and causes DNA hypermethylation. Since the end of 2017, Bernard heads the Laboratory for Functional Epigenetics at the KU Leuven Department of Human Genetics. He developed a comprehensive analysis of cellular heterogeneity in tumours from lung cancer patients, and tools to analyze cell-free DNA methylation at high resolution. His lab currently focuses on deciphering the epigenomic control of cancer cell heterogeneity, and on the development and implementation of novel single cell omics tools.

 

3D mammosphere culture of breast epithelial cell line MCF10A.

Courtesy of Dr. Emer Bourke, NUI Galway

Phospho-Akt expression and localisation

Mediated by VEGF in A549 lung cancer cells. Visualised by high content image analysis.

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

Metaphase chromosome spread of Jurkat T-lymphoma cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Apoptosis assessment of SKMES-1 lung cancer cells

Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

HeLa Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

IACR & EACR Joint Conference 2020

26 — 28 February 2020 at Galway Bay Hotel, Galway

Mitotic Chronic Myelogenous Leukaemia K562 Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Cell to Cell Tweeting

Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC)

Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.

Confocal Microscopy Analysis

Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

EACR Free Membership

The IACR is an affiliated national society and its members benefit from full membership of the EACR.

Save The Date

IACR 2023 Conference
Venue: Athlone Radisson Blu Hotel
Dates:
Wed 22/02/2023 – Fri 24/02/2023

Please check back later in the year for more information.

IACR in the Irish Independent

We supported the Cancer 2022 Campaign from @Mediaplanet

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