Prof. Amanda McCann

Prof. Amanda McCann

UCD

Dr. Amanda McCann PhD, is a Principal Investigator and Senior Conway Fellow in the UCD Conway Institute of Biomolecular and Biomedical Research in University College Dublin (UCD), Ireland. She is also Professor in the UCD School of Medicine and was Head of Pathology within the School from 2015-2018.

Her group’s specific cancer research interests are focused on understanding the mechanisms underlying chemoresistance for women presenting with triple negative breast cancer (TNBC). In this regard she has published extensively in the area of cancer cell senescence and the role of extracellular vesicles/exosomes in the chemoresistant phenotype. She was also a member of the founding committee in the establishment of the International Cellular Senescence Association (ICSA).

In 2016, she established and currently chairs the UCD Patient Voice in Cancer Research (PVCR) committee, made up of patients, researchers and health care professionals, that aims to engage the general public and cancer survivors in cancer research ensuring a two-way dialogue between patients and researchers. In December 2019, she was awarded a VIA (Values in Action) award for her work in this regard.

Within UCD, Amanda has been on an expert panel for the Rapid Realist Review (RRR) detailing the mechanisms that enable the reciprocal involvement of seldom heard groups in health and social care. This initiative was funded through a HRB Ignite award, with the remit that UCD in collaboration with 10 partner organisations develop a network and resource platform to firmly embed patient and public involvement (PPI) in UCD’s research learning and teaching activities.

In relation to patient advocate groups, she previously was a Co-Director of IPPOSI and research advisor to Debra Ireland. In 2017, Amanda was elected President of the Irish Association for Cancer Research (IACR), and has led on patient involvement with cancer researchers across Ireland as part of the annual IACR conferences. As President of the IACR, she represented the association on the European Association for Cancer Research (EACR) National Societies Committee (2018) and was previously Honorary Secretary of the IACR 1998-2000.

 

3D mammosphere culture of breast epithelial cell line MCF10A.

Courtesy of Dr. Emer Bourke, NUI Galway

Phospho-Akt expression and localisation

Mediated by VEGF in A549 lung cancer cells. Visualised by high content image analysis.

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

Metaphase chromosome spread of Jurkat T-lymphoma cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Apoptosis assessment of SKMES-1 lung cancer cells

Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

HeLa Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

IACR & EACR Joint Conference 2020

26 — 28 February 2020 at Galway Bay Hotel, Galway

Mitotic Chronic Myelogenous Leukaemia K562 Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Cell to Cell Tweeting

Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC)

Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.

Confocal Microscopy Analysis

Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

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