
Prof. Adrian Bracken
Principal Investigator at the Smurfit Institute of Genetics, Trinity College Dublin
In 2021, Adrian Bracken was elected an EMBO Member for outstanding achievement in the life sciences. His lab has made several seminal discoveries in the field of cancer epigenetics. In particular, they provided key contributions to the understanding of the molecular mechanisms of how Polycomb group proteins regulate cell-fate decisions in stem cells and in cancer. In research that forms the basis of this talk, his lab recently studied an incurable childhood cancer called ‘H3-K27M-mutant diffuse midline glioma’ and demonstrated that EZH2 inhibitor drugs are a mechanistically anchored treatment strategy, based on modelling the consequences of the H3-K27M cancer causing gene on the underlying biology (Brien et al., Nature Genetics, 2021). His lab is also focused on genetic predisposition to cancer and they are using their expertise in chromatin biology to explore the contribution of regulatory elements in the ‘non-coding genome’. Additionally, several exciting ongoing projects in the lab are studying the roles of chromatin regulators in developmental disorders and other cancer types, including lymphoma.
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