Karen Vousden

Karen Vousden

Fellow of the Royal Society, the Royal Society of Edinburgh, the Academy of Medical Sciences and the European Academy of Sciences

Karen received her PhD from the University of London and following postdoctoral fellowships at the ICR and NCI, she returned to London to establish a research group at the Ludwig Institute. Returning to the US, she was Chief of the Regulation of Cell Growth Laboratory at the NCI before coming back to the UK to take on the role of Director of the CRUK Beatson Institute in Glasgow. In 2016, she became Chief Scientist at CRUK and moved her research group to the Francis Crick Institute in London.

Karen’s research has focused on the tumour suppressor protein p53. She has made contributions to our understanding of how p53 is regulated and the functions of p53 that contribute to its ability to control cancer progression. She revealed an unexpected ability of p53 to help cells adapt and survive under transient periods of nutrient starvation, work that has led to a more general investigation of cancer cell metabolism. More recently, she has been exploring the role of oxidative stress and serine metabolism in cancer development and progression.

Karen is a Fellow of the Royal Society, the Royal Society of Edinburgh, the Academy of Medical Sciences and the European Academy of Sciences. She is a Foreign Member of the National Academy of Sciences and the American Academy of Arts and Sciences, and a fellow of the American Association of Cancer Research. Her awards include the Tenovus Gold Medal, the Sir Frederick Gowland Hopkins Medal, the Royal Medal from the Royal Society of Edinburgh, the Mike Price Gold Medal from the EACR, the Clifford Prize for Cancer Research and the Lombroso Award. In 2010 she was appointed a Commander of the British Empire for services to clinical science.

3D mammosphere culture of breast epithelial cell line MCF10A.

Courtesy of Dr. Emer Bourke, NUI Galway

Phospho-Akt expression and localisation

Mediated by VEGF in A549 lung cancer cells. Visualised by high content image analysis.

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

Metaphase chromosome spread of Jurkat T-lymphoma cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Apoptosis assessment of SKMES-1 lung cancer cells

Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

HeLa Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

IACR & EACR Joint Conference 2020

26 — 28 February 2020 at Galway Bay Hotel, Galway

Mitotic Chronic Myelogenous Leukaemia K562 Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Cell to Cell Tweeting

Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC)

Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.

Confocal Microscopy Analysis

Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

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Latest News

PhD in Tumour Immunology

A fully funded 4-year PhD studentship (€18,000 per annum stipend) is available in the research group of Dr. Aideen Ryan.

Education Grant 2020

The Irish Association for Cancer Research supported five Educational Grants in 2020. These were made available to postgraduate PhD researchers who had been affected by the Covid-19
 pandemic. 

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