EACR Junior & Senior Investigators

WINNERS 2018

Dr Martin Barr, Andrew Binns, Dr Amanda McCann and Dr Naoise Synott

Dr Martin Barr

Dr Martin Barr

Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

The 25th Biennial Congress of the European Association for Cancer Research (EACR25) celebrated its 50th Anniversary this year which was held at the RAI in Amsterdam from June 30th to July 3rd 2018.

Thanks to both the EACR and the IACR, I was honoured to be able to attend this conference as part of my EACR Young Scientist Award.

With the theme ‘From Fundamental Insight to Rational Cancer Treatment’, the congress featured world-class speakers discussing the most innovative current research topics and included a special one-day educational programme ‘Cancer Science for Oncologists’. This consisted of 8 specialized lectures aimed at those working in the field of cancer research, particularly those working as Oncologists or medical practitioners in the cancer space. In addition to the high-profile plenary sessions, the programme offered parallel symposia, allowing participants to build their own scientific programme according to their own specific interests.

One of the key themes of the conference that was of significant interest to my own research was the ‘liquid biopsy’ which was covered extensively between the various sessions. Professor Caroline Dive from Cancer Research UK & the Christie Hospital in Manchester spoke on several occasions on their current strategies and technologies in developing the liquid biopsy as a means to hunting cancer cells that have broken free from tumours and are circulating in the bloodstream in the context of both NSCLC and SCLC. Developing simple blood tests to capture cancer cells could help researchers understand how lung cancer changes as it grows and spreads, and how it can become resistant to treatment.

In turn, this will open up opportunities to develop new therapies to treat this deadly disease more effectively. As an EACR25 participant, there were many opportunities for interacting with other delegates from across Europe through the various workshops, dedicated networking sessions and social events.

Moreover, this interaction was further enhanced during my poster presentation allowing me to initiate new collaborations and receive feedback on my research on DNA repair in NSCLC. One particular highlight of the conference opening was the humorous (yet very true!) portrayal of ‘Love and fear in the lab’ by Professor Uri Alon from the Weizmann Institute of Science in Israel who delivered a talk, on guitar, about the emotional and subjective side of choosing science as a career!

During the course of the conference, a number of plenary talks were delivered by various European investigators leading innovative and discovery cancer research programmes at their relevant Institutions. Professor Karen Vousden, Cancer Research UK’s Chief Scientist and a Group Leader at the Francis Crick Institute was this year’s recipient of the Mike Price Gold Medal Award, a biennial award recognizing a senior researcher who has made exceptional contributions to the progress of cancer research in Europe. She presented some of their novel findings in relation to the regulation of tumour suppressor gene p53 and novel targeted treatments that are currently being developed as novel cancer treatments.

The Pezcoller Foundation-EACR Cancer Researcher Award Lecture was delivered by Professor Jan Korbel, EMBL, Germany who presented work from the Korbel laboratory demonstrating how combining experimental and computational approaches, including single-cell sequencing technology, can be used to unravel determinants and consequences of germline and somatic genetic variation. Professor Korbel and his group are among the pioneers in the utilization of cloud computing to enable sharing and processing of largescale omics data.

The end of this enlightening and successful conference was marked by the EACR 50th Anniversary & Congress Dinner, where the very impressive National Maritime Museum marked the setting for this cultural and social event. A great evening was had among fellow European and Irish cancer researchers, including our very own IACR President, Professor Amanda McCann.

Dr Naoise Synnot

Dr Naoise Synnot

I was honoured to be awarded the EACR Young Scientist (Junior Category) Award at the Irish Association of Cancer Research Annual meeting in February 2018. As a result I received free registration to The 25th Biennial Congress of the European Association for Cancer Research which celebrated the EACR’s 50th Anniversary Year.

This landmark Congress took place in the RAI Convention Centre in Amsterdam, from 30 June to 3 July 2018.

The EACR Congress brings together 1,800 basic, preclinical and translational researchers from across the full breadth of research fields, providing an excellent opportunity to interact with fellow cancer researchers and even form new collaborations. I was lucky enough to be selected to present my research in a poster form at the meeting. During my allotted time I was visited by a number of researchers from across Europe. This provided a wonderful opportunity for me to both discuss and evaluate my research. With the exchange of emails and new ideas for experiments, I was eager to return to the lab and explore my project further after this session!

In addition to presenting my work at the conference I attended a number of excellent talks from an array of internationally acclaimed invited speakers. The theme of the Congress was ‘From Fundamental Insight to Rational Cancer Treatment’, covering the journey of discovery and development ‘from bench to bedside’. As a translational cancer research, I was delighted that the Congress covered focused on this area. In particular I eager to attend the Mike Price Gold Medal Award Lecture entitled ‘How does p53 impact cancer development? Let me count the ways’’ by Prof Karen Vousden, Chief Scientist at CRUK and Group Leader at the Francis Crick Institute. Professor Vousden’s research focuses on the tumour suppressor protein p53, which was the protein of interest for my doctoral studies. Prof Vousden’s presentation did not disappoint and as the final talk of the meeting, it finished the EACR Congress on a high for me.

Overall, I found the meeting highly informative, with a diverse group of attendees who are friendly, eager to discuss their work and proud cancer researchers. I am grateful to now be part of the EACR community and I look forward to EACR 2020!

3D mammosphere culture of breast epithelial cell line MCF10A.

Courtesy of Dr. Emer Bourke, NUI Galway

Phospho-Akt expression and localisation

Mediated by VEGF in A549 lung cancer cells. Visualised by high content image analysis.

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

Metaphase chromosome spread of Jurkat T-lymphoma cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Apoptosis assessment of SKMES-1 lung cancer cells

Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

HeLa Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

IACR & EACR Joint Conference 2020

26 — 28 February 2020 at Galway Bay Hotel, Galway

Mitotic Chronic Myelogenous Leukaemia K562 Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Cell to Cell Tweeting

Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC)

Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.

Confocal Microscopy Analysis

Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

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