Dr Tríona Ní­ Chonghaile

Dr Tríona Ní­ Chonghaile

Senior Council Member

Dr Tríona Ní­ Chonghaile joined the Royal College of Surgeons in Ireland, as a StAR Research Lecturer in 2015. She started her scientific career with a first class honours degree in Biomedical Science from the National University of Ireland, Galway (NUIG).

She then went on to complete her PhD in Biochemistry (NUIG) in 2008, studying the role of BCL-2 family members in endoplasmic reticulum stress. Her interest in the BCL-2 family members led her to pursue a clinically relevant post-doctoral fellowship at the Dana-Farber Cancer Institute/Harvard Medical School with Prof. Anthony Letai. There she received a Multiple Myeloma Research Fellowship to develop novel tools for personalised medicine. During her postdoc, she was involved in numerous collaborative multi-disciplinary projects and published first-author papers in high-impact journals, including Science and Cancer Discovery.

In 2014, she returned to Ireland and joined the laboratory of Prof. William Gallagher at University College Dublin, as a Research Fellow. While there she received the European Association of Cancer Research Senior Young Scientist Award (2014) and the prestigious L’Oréal-UNESCO For Women in Science Award (2015).

The main focus of Dr Ní Chonghaile’s research is based on trying to understand why certain cancers are sensitive to chemotherapy, while others are resistant and how best to treat resistant cancers using novel drug discovery approaches. The main research interests are mitochondrial apoptosis, epigenetic regulation of apoptosis and haematological malignancies, with a particular interest in T-cell leukaemia.

3D mammosphere culture of breast epithelial cell line MCF10A.

Courtesy of Dr. Emer Bourke, NUI Galway

Phospho-Akt expression and localisation

Mediated by VEGF in A549 lung cancer cells. Visualised by high content image analysis.

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

Metaphase chromosome spread of Jurkat T-lymphoma cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Apoptosis assessment of SKMES-1 lung cancer cells

Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

HeLa Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

IACR & EACR Joint Conference 2020

26 — 28 February 2020 at Galway Bay Hotel, Galway

Mitotic Chronic Myelogenous Leukaemia K562 Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Cell to Cell Tweeting

Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC)

Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.

Confocal Microscopy Analysis

Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

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Education Grant 2020

The Irish Association for Cancer Research supported five Educational Grants in 2020. These were made available to postgraduate PhD researchers who had been affected by the Covid-19
 pandemic. 

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