
Dr Tríona Ní Chonghaile PhD
Department of Physiology and Medical Physics, Royal College of Surgeons
In
She completed her
Dr. Ní Chonghaile’s lab is interested in understanding why certain cancers are sensitive to
Based on her work, she received the European Association of Cancer Research (senior) young scientist of the year award (2014), along with receiving the prestigious L’Oréal-UNESCO For Women in Science UK&I Fellowship (2015). Her research is funded by grants from SFI-HRB-Wellcome Trust, H2020 and Breast Cancer Now. She has published in high-impact journals including first author papers Science and Cancer Discovery.
Abstract:
Cytotoxic chemotherapy is the standard of care for patients with triple negative breast cancer (TNBC).
Most patients with advanced TNBC progress after chemotherapy and die from metastatic disease. Currently, no established targeted therapeutics or biomarkers of outcome/response have been clinically approved in the context of TNBC. To identify novel therapeutics for the treatment of chemoresistant TNBC, we performed a high-throughput screen to identify small molecules that are cancer selective but can kill drug-resistant TNBC cells.
We screened a total of 30,000 compounds. To identify the mechanism of action of the lead compound we used a genetic approach to generate an RNAi signature for the compound, which indicated the lead compound was most likely that of histone deacetylase inhibitor (HDAC). Using an in vitro HDAC inhibitor screen, we identified that the compound specifically inhibited HDAC6. We are currently studying the role of HDAC6 in TNBC cells.
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