Dr Simone Marcone

Senior Council Member

Dr Simone Marcone is a Senior Research Fellow and Lecturer in Translational Oncology in the Department of Surgery at Trinity College Dublin. He obtained his BSc (Hons) in Pharmaceutical chemistry in 2007 in “La Sapienza” University in Rome-Italy, and a PhD in molecular medicine at University College Dublin in 2013.

Simone is an experienced cancer researcher with expertise in cancer biology and precision medicine approaches towards the development of novel diagnostic platforms and therapeutic strategies to treat cancer. His highly inter-disciplinary research lies at the interface between cell and molecular biology, medicinal chemistry & translational research, and has led to the
development of important research models in the cancer space.

Simone`s research focusses on two main thematic areas: the elucidation of the mechanisms regulating cancer development and progression; and the use of translational research for the discovery and development of novel diagnostics and therapeutics.

Simone`s research current goals are to develop novel nanotherapeutics to increase the response to radiotherapy in those oesophageal cancer patients with a poor response to treatment, and to determine the mechanisms regulating resistance to cancer treatment.

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3D mammosphere culture of breast epithelial cell line MCF10A.

Courtesy of Dr. Emer Bourke, NUI Galway

Phospho-Akt expression and localisation

Mediated by VEGF in A549 lung cancer cells. Visualised by high content image analysis.

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

Metaphase chromosome spread of Jurkat T-lymphoma cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Apoptosis assessment of SKMES-1 lung cancer cells

Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

HeLa Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

IACR & EACR Joint Conference 2020

26 — 28 February 2020 at Galway Bay Hotel, Galway

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Mitotic Chronic Myelogenous Leukaemia K562 Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Cell to Cell Tweeting

Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC)

Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.

Confocal Microscopy Analysis

Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

EACR Free Membership

The IACR is an affiliated national society and its members benefit from full membership of the EACR.

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Save The Date

IACR 2023 Conference
Venue: Athlone Radisson Blu Hotel
Dates: Wed 22/02/2023 – Fri 24/02/2023

Please check back later in the year for more information.

IACR in the Irish Independent

We supported the Cancer 2022 Campaign from @Mediaplanet

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