Dr. Seth Coffelt

Senior Research Fellow within the Institute of Cancer Sciences at the University of Glasgow

Seth Coffelt is a Senior Research Fellow within the Institute of Cancer Sciences at the University of Glasgow. His lab is based at the Cancer Research UK Beatson Institute. Seth obtained his Ph.D. from Tulane University in New Orleans, Louisiana, USA, in 2006. He undertook his first postdoc position at the University of Sheffield in the UK where he studied the role of macrophages in tumor progression.

Afterwards, Seth was awarded a Marie Curie Intra-European Career Development Fellowship to join Karin de Visser’s lab at the Netherlands Cancer Institute in Amsterdam. During this time, Seth discovered how immune cells cooperate with each other to promote metastasis through the suppression of other immune cells. Seth moved to Scotland in the summer of 2016 to focus on the molecular mechanisms that regulate gamma delta T cell function during the evolution of metastasis and cancer progression. Seth was awarded the British Association for Cancer Research AstraZeneca Young Scientist Frank Rose Award for 2018.

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3D mammosphere culture of breast epithelial cell line MCF10A.

Courtesy of Dr. Emer Bourke, NUI Galway

Phospho-Akt expression and localisation

Mediated by VEGF in A549 lung cancer cells. Visualised by high content image analysis.

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

Metaphase chromosome spread of Jurkat T-lymphoma cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Apoptosis assessment of SKMES-1 lung cancer cells

Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

HeLa Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

IACR & EACR Joint Conference 2020

26 — 28 February 2020 at Galway Bay Hotel, Galway

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Mitotic Chronic Myelogenous Leukaemia K562 Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Cell to Cell Tweeting

Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC)

Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.

Confocal Microscopy Analysis

Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

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