Dr Richard Turkington MB BCh BAO BSc MRCP PhD

Dr Richard Turkington MB BCh BAO BSc MRCP PhD

Senior Council Member

Clinical Senior Lecturer in Medical Oncology

I am a Clinical Senior Lecturer in Medical Oncology at the Centre for Cancer Research and Cell Biology, Queen’s University Belfast and an Honorary Consultant at the Northern Ireland Cancer Centre with an interest in oesophago-gastric cancer. Having graduated in medicine from Queen’s University Belfast I began specialty training in Medical Oncology in 2005.

In 2007 I was awarded a Cancer Research UK Bobby Moore Clinical Research Fellowship to pursue a PhD in novel drug target discovery in colo-rectal cancer under the supervision of Professor Patrick Johnston. Following completion of my Phd I was appointed as an Academic Clinical Lecturer in the field of oesophago-gastric cancer and in 2013 became a Visiting Research Fellow at the Hutchison/MRC Cancer Unit, University of Cambridge, under the supervision of Professor Rebecca Fitzgerald.

My work has been published in high impact journals and in 2014 I received the American Society of Clinical Oncology Merit Award. My principle research interests include oesophago-gastric cancer and the analysis of genomic datasets for the discovery of biomarkers and mechanisms of resistance to chemotherapeutic agents. These discoveries are being translated into clinical advances through the implementation of biomarker-led clinical trials. As part of the oesophago-gastric cancer team at Queen’s University Belfast I seek to transform the care of oesophago-gastric patients through the integration of laboratory discoveries, translational science and clinical research.

3D mammosphere culture of breast epithelial cell line MCF10A.

Courtesy of Dr. Emer Bourke, NUI Galway

Phospho-Akt expression and localisation

Mediated by VEGF in A549 lung cancer cells. Visualised by high content image analysis.

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

Metaphase chromosome spread of Jurkat T-lymphoma cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Apoptosis assessment of SKMES-1 lung cancer cells

Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

HeLa Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

IACR & EACR Joint Conference 2020

26 — 28 February 2020 at Galway Bay Hotel, Galway

Mitotic Chronic Myelogenous Leukaemia K562 Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Cell to Cell Tweeting

Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC)

Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.

Confocal Microscopy Analysis

Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

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Education Grants

The Irish Association for Cancer Research will support a limited number of Educational Grants that
will be made available to postgraduate PhD researchers who have been affected by the Covid-19
pandemic. We acknowledge that many of our members have been significantly impacted by the
recent pandemic that may have affected their ability to continue and/or complete research projects.

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