Dr Paul Murray

Dr Paul Murray

Professor of Molecular Pathology in the Health Research Institute, University of Limerick

Paul Murray is Professor of Molecular Pathology in the Health Research Institute, University of Limerick having joined from the University of Birmingham at the beginning of 2019.

Paul obtained his PhD in 1996 working on the contribution of the Epstein-Barr virus to the pathogenesis of Hodgkin lymphoma with Professor Lawrence Young at the University of Birmingham. He was a Fulbright Fellow in the Ambinder lab’ at the Johns Hopkins University, Baltimore, USA before setting up his own laboratory in the Department of Pathology at the University of Birmingham in 2000. In 2007, he moved to the Institute of Cancer Studies, at the University of Birmingham, holding concurrent Cancer Research UK and Leukaemia Research Fund Programme grants as well as a number of project grants, including UK Medical Research Council awards. He has published over 150 papers with an H-index of 61.

Research in the Murray Group is focused on the discovery of molecular pathways involved in the development and progression of aggressive cancers derived from mature lymphocytes (the lymphomas). These include the most common form of this disease, called diffuse large B cell lymphoma, a tumour recently defined as one of four haematological cancers with the highest unmet clinical need. Our objective is to better understand the pathogenesis of these malignancies and in doing so develop novel therapeutic approaches. For example, we are interested in the possibility that collagen within the tumour ‘microenvironment’ can cause the cancerous cells to spread around the body and to the central nervous system where they can have devastating consequences. We have already identified novel ways to block collagen and so potentially provide new treatments to cure patients at an earlier stage before the tumour spreads.

3D mammosphere culture of breast epithelial cell line MCF10A.

Courtesy of Dr. Emer Bourke, NUI Galway

Phospho-Akt expression and localisation

Mediated by VEGF in A549 lung cancer cells. Visualised by high content image analysis.

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

Metaphase chromosome spread of Jurkat T-lymphoma cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Apoptosis assessment of SKMES-1 lung cancer cells

Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

HeLa Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

IACR & EACR Joint Conference 2020

26 — 28 February 2020 at Galway Bay Hotel, Galway

Mitotic Chronic Myelogenous Leukaemia K562 Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Cell to Cell Tweeting

Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC)

Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.

Confocal Microscopy Analysis

Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

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Education Grant 2020

The Irish Association for Cancer Research supported five Educational Grants in 2020. These were made available to postgraduate PhD researchers who had been affected by the Covid-19
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