Dr Niamh Buckley

Dr Niamh Buckley

Senior Council Member

 

Dr Niamh Buckley graduated from Trinity College, Dublin in 2002 with a First Class Honours Degree in Biochemistry. She then carried out her Ph.D. training in the Department of Oncology (Queen’s University Belfast) under the supervision of Prof. Paul Harkin. Following this, she then worked as a post-doctoral researcher with Dr Paul Mullan in the Centre for Cancer Research and Cell Biology (Queen’s University Belfast). During this time she investigated the role of the breast and ovarian tumour suppressor gene, BRCA1, in stem cell regulation and mammary gland differentiation.

Dr Buckley was awarded the prestigious Breast Cancer Now fellowship in 2013 to develop novel biomarkers and therapeutic strategies in BRCA1-mutant and/or triple negative breast cancer. In 2016 she was appointed as a Lecturer in Personalised Medicine and Pharmacogenomics in the School of Pharmacy (Queen’s University Belfast). Her research focuses on the integration of in vitro, in vivo, bioinformatics and pathology approaches to identify key pathways underpinning poor outcome breast cancer and use detailed knowledge of this biology to identify appropriate targeted treatment options, personalising therapy in an area of unmet clinical need.

Dr Buckley’s work has led to a number of significant publications in leading cancer research journals and she has been the recipient of several prestigious awards including European Association of Cancer Research (EACR) Young Scientist Award (2012), Roche Gold Medal Award (2011) and School of Medicine, Dentistry and Biomedical Sciences Post-Doctoral Researcher of the Year (2012).

3D mammosphere culture of breast epithelial cell line MCF10A.

Courtesy of Dr. Emer Bourke, NUI Galway

Phospho-Akt expression and localisation

Mediated by VEGF in A549 lung cancer cells. Visualised by high content image analysis.

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

Metaphase chromosome spread of Jurkat T-lymphoma cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Apoptosis assessment of SKMES-1 lung cancer cells

Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

HeLa Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

IACR & EACR Joint Conference 2020

26 — 28 February 2020 at Galway Bay Hotel, Galway

Mitotic Chronic Myelogenous Leukaemia K562 Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Cell to Cell Tweeting

Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC)

Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.

Confocal Microscopy Analysis

Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

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Education Grants

The Irish Association for Cancer Research will support a limited number of Educational Grants that
will be made available to postgraduate PhD researchers who have been affected by the Covid-19
pandemic. We acknowledge that many of our members have been significantly impacted by the
recent pandemic that may have affected their ability to continue and/or complete research projects.

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