Dr Marie McIlroy

Dr Marie McIlroy

Lecturer, Department of Surgery, Royal College of Surgeons Dublin

Dr Marie McIlroy completed her PhD studies under the supervision of Prof Tracy Robson in 2003.  This led to a post-doctorate position at Ulster University, Coleraine where she studied the role of Cyp1B1 in the progression of esophageal tumorigenesis. The desire to conduct more translational cancer research led to a move to UCD where she joined the research group of Prof Leonie Young at the Conway Institute. 

During her post-doctoral training, she developed a keen interest in the steroid microenvironment and how it may impact mechanisms of resistance to endocrine therapy in breast cancer.  Identification of the estrogen down-regulated transcription factor, HOXC11, as a poor prognostic indicator led to a number of high impact publications and patent filings. More recently, her research has focused on the potential for androgenic steroid precursors to facilitate resistance via altering gene expression and increasing metabolic flexibility.     

In 2014 she was appointed as lecturer at the Royal College of Surgeons in Ireland within the Department of Surgery. She co-ordinates the undergraduate Molecular Medicine module and a post-graduate training workshop in Applied Biomedical Imaging. Marie is a strong advocate for career guidance for PhD scholars and coordinates interactive career workshops in conjunction with the postgraduate school. She has received funding in excess of €1 M from national and international funding agencies and, in addition, has successfully established a number of industry collaborations. 

3D mammosphere culture of breast epithelial cell line MCF10A.

Courtesy of Dr. Emer Bourke, NUI Galway

Phospho-Akt expression and localisation

Mediated by VEGF in A549 lung cancer cells. Visualised by high content image analysis.

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

Metaphase chromosome spread of Jurkat T-lymphoma cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Apoptosis assessment of SKMES-1 lung cancer cells

Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

HeLa Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

IACR & EACR Joint Conference 2020

26 — 28 February 2020 at Galway Bay Hotel, Galway

Mitotic Chronic Myelogenous Leukaemia K562 Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Cell to Cell Tweeting

Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC)

Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.

Confocal Microscopy Analysis

Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

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Education Grant 2020

The Irish Association for Cancer Research supported five Educational Grants in 2020. These were made available to postgraduate PhD researchers who had been affected by the Covid-19
 pandemic. 

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