Dr Margaret McGee
Senior Council Member
Dr. Margaret Mc Gee is an Associate Professor in the School of Biomolecular and Biomedical Science, University College Dublin (UCD) and Principal Investigator/Fellow in the UCD Conway Institute of Biomolecular and Biomedical Research.
Dr. Mc Gee leads a translational research group that is focussed on understanding processes that contribute to the development and progression of cancer, with particular emphasis on haematopoietic malignancies such as acute myeloid leukaemia (AML), chronic lymphocytic leukaemia (CLL) and multiple myeloma (MM), with the view to identifying novel therapeutic targets and the development of new targeted therapies.
The team is particularly interested in understanding how bone marrow cells facilitate the progression of haematopoietic malignancies and is investigating the role of secreted proteins and extracellular vesicles on tumour cell migration, invasion and altered immune cell function. They use genomic and proteomic technologies, together with cell and biochemical approaches to identify and validate new therapeutic targets. Through ongoing translational research collaborations the group is conducting pre-clinical investigation of a number of novel therapeutics for treatment of haematological malignancies.
Before joining UCD, Dr Mc Gee completed a PhD and postdoc in the School of Biochemistry and Immunology in Trinity College Dublin. Since 2004, Dr. Mc Gee’s independent research has been funded by Science Foundation Ireland, Irish Cancer Society, Irish Research Council and a joint UCD-SFI-HRB-Wellcome Trust Career Stimulus Award.
3D mammosphere culture of breast epithelial cell line MCF10A.
Courtesy of Dr. Emer Bourke, NUI Galway
Phospho-Akt expression and localisation
Mediated by VEGF in A549 lung cancer cells. Visualised by high content image analysis.
Metaphase chromosome spread of Jurkat T-lymphoma cells
Apoptosis assessment of SKMES-1 lung cancer cells
Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).
Mitotic Chronic Myelogenous Leukaemia K562 Cells
Cell to Cell Tweeting
Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC)
Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.
Confocal Microscopy Analysis
Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).
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