Dr Margaret McGee

Dr Margaret McGee

Senior Council Member

 

Dr. Margaret Mc Gee is an Associate Professor in the School of Biomolecular and Biomedical Science, University College Dublin (UCD) and Principal Investigator/Fellow in the UCD Conway Institute of Biomolecular and Biomedical Research.

Dr. Mc Gee leads a translational research group that is focussed on understanding processes that contribute to the development and progression of cancer, with particular emphasis on haematopoietic malignancies such as acute myeloid leukaemia (AML), chronic lymphocytic leukaemia (CLL) and multiple myeloma (MM), with the view to identifying novel therapeutic targets and the development of new targeted therapies.

The team is particularly interested in understanding how bone marrow cells facilitate the progression of haematopoietic malignancies and is investigating the role of secreted proteins and extracellular vesicles on tumour cell migration, invasion and altered immune cell function. They use genomic and proteomic technologies, together with cell and biochemical approaches to identify and validate new therapeutic targets. Through ongoing translational research collaborations the group is conducting pre-clinical investigation of a number of novel therapeutics for treatment of haematological malignancies.

Before joining UCD, Dr Mc Gee completed a PhD and postdoc in the School of Biochemistry and Immunology in Trinity College Dublin. Since 2004, Dr. Mc Gee’s independent research has been funded by Science Foundation Ireland, Irish Cancer Society, Irish Research Council and a joint UCD-SFI-HRB-Wellcome Trust Career Stimulus Award.

3D mammosphere culture of breast epithelial cell line MCF10A.

Courtesy of Dr. Emer Bourke, NUI Galway

Phospho-Akt expression and localisation

Mediated by VEGF in A549 lung cancer cells. Visualised by high content image analysis.

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

Metaphase chromosome spread of Jurkat T-lymphoma cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Apoptosis assessment of SKMES-1 lung cancer cells

Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

HeLa Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

IACR & EACR Joint Conference 2020

26 — 28 February 2020 at Galway Bay Hotel, Galway

Mitotic Chronic Myelogenous Leukaemia K562 Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Cell to Cell Tweeting

Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC)

Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.

Confocal Microscopy Analysis

Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

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Education Grants

The Irish Association for Cancer Research will support a limited number of Educational Grants that
will be made available to postgraduate PhD researchers who have been affected by the Covid-19
pandemic. We acknowledge that many of our members have been significantly impacted by the
recent pandemic that may have affected their ability to continue and/or complete research projects.

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