Dr Kyle Matchett

Dr Kyle Matchett

Junior Council Member

 

Dr Kyle Matchett completed his PhD in October 2010 at Queen’s University Belfast (QUB). His thesis examined the expression of SEPT9 splice variants in ovarian tumours from the SCOTROC clinical trial and array CGH studies with the Institute of Cancer Research, London.

Following his PhD, Dr Matchett was appointed as a Cancer Research UK Postdoctoral Research Fellow at QUB. He discovered that estrogen metabolism is deregulated in BRCA1-deficient breast cells leading to increased production of estrogen metabolites and metabolite-induced DNA damage. Dr Matchett published his work in Cancer Research, and presented it at conferences in Montreal, London and Amsterdam. In recognition of this research, Dr Matchett was awarded the inaugural Professor John Fitzpatrick Prize by the Irish Association for Cancer Research (IACR).

Dr Matchett continued his interest in hormone signalling in breast cancer and moved to take up an EU FP7 Postdoctoral Research Fellow position focused on understanding the role of erythropoietin (EPO) in breast cancer. Based at QUB, his post involved collaboration and extensive travel with partner laboratories in Madrid, Innsbruck, Tel-Aviv, Vienna, Munich and Zurich. During this time, Dr Matchett played a key role in the development of novel EPO receptor antibodies with industrial partners Aldevron (Germany). He also led his own research which resulted in several publications.

In 2015, Dr Matchett was appointed as a Leukaemia and Leukaemia NI Postdoctoral Research Fellow following an increasing interest in haematology. His research focused on developing novel therapeutics for paediatric and adult acute myeloid leukaemia. This work has been recognised both nationally and internationally with a number of grants, invited talks and awards, including a presentation prize at XXXVI World Congress of the International Society of Haematology (2016), Little Princess Trust/Childhood Cancer and Leukaemia Group Project Grant Awards (2017, 2018) and a Novartis Fellowship Prize and Medal (2017).

In addition to his research programme, Dr Matchett completed his PGCHET in 2014 and was awarded a Fellowship of the Higher Education in 2015. He co-led a School-wide study examining postgraduate research student support, which was published in 2018.

Dr Matchett was appointed as a Lecturer at Ulster University in October 2018.

Dr Matchett was appointed onto the inaugural IACR Junior Council in 2015 and co-led a number of pioneering Junior Council initiatives including the Young Investigators Wednesday Night Session, Networking Session, and Irish Cancer Society-sponsored Media Training. He has co-authored three IACR meeting reports.

3D mammosphere culture of breast epithelial cell line MCF10A.

Courtesy of Dr. Emer Bourke, NUI Galway

Phospho-Akt expression and localisation

Mediated by VEGF in A549 lung cancer cells. Visualised by high content image analysis.

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

Metaphase chromosome spread of Jurkat T-lymphoma cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Apoptosis assessment of SKMES-1 lung cancer cells

Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

HeLa Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

IACR & EACR Joint Conference 2020

26 — 28 February 2020 at Galway Bay Hotel, Galway

Mitotic Chronic Myelogenous Leukaemia K562 Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Cell to Cell Tweeting

Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC)

Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.

Confocal Microscopy Analysis

Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

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Education Grants

The Irish Association for Cancer Research will support a limited number of Educational Grants that
will be made available to postgraduate PhD researchers who have been affected by the Covid-19
pandemic. We acknowledge that many of our members have been significantly impacted by the
recent pandemic that may have affected their ability to continue and/or complete research projects.

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