Dr. Joanne Lysaght

Dr. Joanne Lysaght

Senior Council Member

Dr. Joanne Lysaght is an Associate Professor at Trinity College Dublin and leads the Cancer Immunology and Immunotherapy Group in the Trinity Translational Medicine Institute at St. James’s Hospital. She is course coordinator for the M.Sc. in Translational Oncology.

Her research group focuses on the impact of obesity on anti-tumour immune responses in gastrointestinal cancer patients, with a particular focus on T lymphocytes. We also examine the impact of obesity on hepatic inflammation and post-operative recovery and elucidating the role of adaptive immunity in the progression of pre-malignant conditions to cancer.

In addition, a large component of our research is focused on identifying and developing new immunotherapeutic strategies and targets for gastrointestinal cancers, through targeting chemokine pathways and cellular metabolism, identifying the impact of standard therapies such as chemotherapy and radiotherapy on immune cells and the best combination approaches with immunotherapy. This work mainly focuses on immune checkpoint inhibitors and developing approaches to circumvent immune evasion in order to boost response rates to immunotherapy.

In addition, we are also investigating the role of inflammation in conditions such as cancer cachexia and the use of inflammatory markers such as CRP as a diagnostic tool. Dr. Lysaght’s research is funded by grants from HRB, Irish Research Council and the Irish Cancer Society.

3D mammosphere culture of breast epithelial cell line MCF10A.

Courtesy of Dr. Emer Bourke, NUI Galway

Phospho-Akt expression and localisation

Mediated by VEGF in A549 lung cancer cells. Visualised by high content image analysis.

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

Metaphase chromosome spread of Jurkat T-lymphoma cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Apoptosis assessment of SKMES-1 lung cancer cells

Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

HeLa Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

IACR & EACR Joint Conference 2020

26 — 28 February 2020 at Galway Bay Hotel, Galway

Mitotic Chronic Myelogenous Leukaemia K562 Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Cell to Cell Tweeting

Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC)

Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.

Confocal Microscopy Analysis

Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

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The Irish Association for Cancer Research will support a limited number of Educational Grants that
will be made available to postgraduate PhD researchers who have been affected by the Covid-19
pandemic. We acknowledge that many of our members have been significantly impacted by the
recent pandemic that may have affected their ability to continue and/or complete research projects.

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