Dr James Brown

Dr James Brown

Senior Council Member

Dr Brown is a Group leader and Lecturer in the Biological Sciences Department at the University of Limerick. The major research interest of his group is in how acetylation regulates genome stability, particularly in response to DNA double strand breaks (DSB) in a breast cancer model. His translational work is focused on pre-clinical and early clinical validation of small molecules he developed which target specific lysine acetyltransferases (KATi). Further research interests include investigating and validating novel breast cancer biomarkers (proteins and miRNA), for improved patient stratification and to enhance our understanding of the molecular changes seen in breast cancer.

 

Dr Brown received his B.App.Sc.(Hons) through the Queensland University of Technology (Brisbane, Australia) and completed his PhD at the Queensland Institute of Medical Research (Brisbane, Australia), investigating the cellular mechanisms for detecting and responding to DNA damage and genotoxic stress. Subsequently he moved to NUI Galway undertaking further postdoctoral training, before taking up his current post in the University of Limerick.

 

His work has resulted in a number of important publications and he received the prestigious Irish Association for Cancer Research European Young Scientist Award (2015) for his work on developing KATi. He is involved in several major international collaborations further developing and exploring his KATi in a number of diseases. Dr Brown was the first Chair of the IACR Junior council, is currently an associate member of the Centre for Chromosome Biology and sits on the Biochemical Society Early Career Advisory Panel.

3D mammosphere culture of breast epithelial cell line MCF10A.

Courtesy of Dr. Emer Bourke, NUI Galway

Phospho-Akt expression and localisation

Mediated by VEGF in A549 lung cancer cells. Visualised by high content image analysis.

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

Metaphase chromosome spread of Jurkat T-lymphoma cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Apoptosis assessment of SKMES-1 lung cancer cells

Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

HeLa Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

IACR & EACR Joint Conference 2020

26 — 28 February 2020 at Galway Bay Hotel, Galway

Mitotic Chronic Myelogenous Leukaemia K562 Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Cell to Cell Tweeting

Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC)

Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.

Confocal Microscopy Analysis

Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

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Education Grant 2020

The Irish Association for Cancer Research supported five Educational Grants in 2020. These were made available to postgraduate PhD researchers who had been affected by the Covid-19
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