Dr Graham Pidgeon

Dr Graham Pidgeon

Honorary Secretary

 

Dr Graham Pidgeon is an Associate Professor at Trinity College Dublin and a principal investigator at the Trinity Translational Medicine Institute at St. James’s Hospital. He established the MSc in Translational Oncology at TCD in 2012 and has acted as Director and Course co-ordinator for that program.

Dr Pidgeon’s research interests focus on the molecular pathways linking excess adipose tissue and visceral obesity with tumour development, progression and response to treatment in a range of solid malignancies. The group have a particular interest in the molecular pathways activated in cancer cells within the obese tumour microenvironment, including the activation of immune cell subsets in visceral adipose tissue, alterations in tumour metabolism and how obesity drives the EMT process in solid malignancies.

Other areas of interest include the role of bioactive lipid enzymes, including cycloxygenase and lipoxygenase, in tumour cell signalling pathways and metastasis. Recent research has focused on the combination of molecular targeted therapies with chemotherapy and radiation therapy in gastrointestinal cancers. Through national and international collaborations the group are investigating the potential of novel pharmacological and naturally occurring LOX inhibitors as anti-angiogenic and anti-cancer agents.

The ultimate aim of this research program is to identify novel therapeutic targets that may prevent the development and/or progression of multiple cancers, through understanding the molecular mechanisms behind the disease.

3D mammosphere culture of breast epithelial cell line MCF10A.

Courtesy of Dr. Emer Bourke, NUI Galway

Phospho-Akt expression and localisation

Mediated by VEGF in A549 lung cancer cells. Visualised by high content image analysis.

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

Metaphase chromosome spread of Jurkat T-lymphoma cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Apoptosis assessment of SKMES-1 lung cancer cells

Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

HeLa Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

IACR & EACR Joint Conference 2020

26 — 28 February 2020 at Galway Bay Hotel, Galway

Mitotic Chronic Myelogenous Leukaemia K562 Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Cell to Cell Tweeting

Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC)

Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.

Confocal Microscopy Analysis

Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

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Education Grant 2020

The Irish Association for Cancer Research supported five Educational Grants in 2020. These were made available to postgraduate PhD researchers who had been affected by the Covid-19
 pandemic. 

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