Dr Elizabeth Ryan

Dr Elizabeth Ryan

Senior Council Member

Elizabeth Ryan is a Lecturer in Immunology at the Department of Biological Sciences and Investigator in the Health Research Institute and Biomaterials cluster of the Bernal Institute at the University of Limerick.

Dr. Ryan received her PhD in Immunology in 2000 on the topic of Whooping Cough vaccination with Prof. Kingston Mills. She then undertook a post-doctoral fellowship in the laboratory of Prof. Ed Clark at the University of Washington, Seattle where she made significant contribution to understanding how human dendritic cells activate B cells. This was followed by a Marie Curie Fellowship at the Immunology Research Department of Sanofi-Pasteur, Lyon.

In 2005 she returned to Ireland to where she developed a translational immunology research programme in collaboration with Prof. Cliona O’Farrelly on liver dendritic cells and response to the Hepatitis C virus. From 2010-2018 she was Senior Scientist at the Centre for Colorectal Disease at St. Vincent’s Hospital. Where she led a translational research programme in colorectal cancer and inflammatory bowel disease.

Her current research benefits from her wide experience in vaccination, viral and bacterial infection and translational research to focus on understanding the role of human myeloid cells (macrophages/dendritic cells) play in controlling inflammation.

She is particularly interested in how these important immune cells might be manipulated by the local tissue environment in diseases such as Inflammatory Bowel Disease and Colorectal Cancer.

3D mammosphere culture of breast epithelial cell line MCF10A.

Courtesy of Dr. Emer Bourke, NUI Galway

Phospho-Akt expression and localisation

Mediated by VEGF in A549 lung cancer cells. Visualised by high content image analysis.

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

Metaphase chromosome spread of Jurkat T-lymphoma cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Apoptosis assessment of SKMES-1 lung cancer cells

Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

HeLa Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

IACR & EACR Joint Conference 2020

26 — 28 February 2020 at Galway Bay Hotel, Galway

Mitotic Chronic Myelogenous Leukaemia K562 Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Cell to Cell Tweeting

Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC)

Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.

Confocal Microscopy Analysis

Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

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Education Grant 2020

The Irish Association for Cancer Research supported five Educational Grants in 2020. These were made available to postgraduate PhD researchers who had been affected by the Covid-19
 pandemic. 

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