Dr David Hughes

Dr David Hughes

Senior Council Member

Dr David Hughes joined the Conway Institute in University College Dublin (UCD) in 2017 where his research focuses on nutritional, genetic and microbial epidemiology of various cancer sites. Previously he has worked at the RCSI, TCD, the WHO International Agency for Research on Cancer, and the Sanger Institute. He currently leads large prospective cohort studies in the European Prospective Investigation of Cancer and Nutrition (EPIC) of the influence of bacterial antigens and nutritional status of micronutrient minerals on risk of cancer at various organ sites. Recent findings of his studies within EPIC include that antigens to Streptococcus gallolyticus in advance of cancer diagnosis are associated with colorectal cancer risk, pre-diagnostic selenium status is associated with colorectal and liver cancer risk, and that pre-diagnostic zinc and copper concentrations are also associated with risk of these cancers. e.g. PUBMED PMIDs 28415859, 28575311, 28152549, 27357089, 25042282; Click on the interview link to find out more. 

He received his BSc Biochemistry degree from the University of Leeds in 1990, his PhD in Medical Genetics from Queen’s University Belfast in 1996, and a Postgraduate Diploma in Health Professions Education at the RCSI in 2015. He is a member of the EPIC steering committee, the senior council of the Irish Association of Cancer Research, the International Cancer Microbiome Consortium (inaugurated 2017), and the new Irish Cancer Epidemiology Network (inaugurated 2018). Principal funders are the Health Research Board, the World Cancer Research Fund, and various funders for the EPIC project.

3D mammosphere culture of breast epithelial cell line MCF10A.

Courtesy of Dr. Emer Bourke, NUI Galway.

Phospho-Akt expression and localisation

Mediated by VEGF in A549 lung cancer cells
Visualised by high content image analysis.

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

Metaphase chromosome spread of Jurkat T-lymphoma cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD  

Apoptosis assessment of SKMES-1 lung cancer cells

Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

HeLa Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

55th Annual Conference 2019

20 — 22 February 2019 at Europa Hotel, Belfast

Mitotic Chronic Myelogenous Leukaemia K562 Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Cell to Cell Tweeting

Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC) 

Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.

Confocal microscopy analysis

Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

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pandemic. We acknowledge that many of our members have been significantly impacted by the
recent pandemic that may have affected their ability to continue and/or complete research projects.

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