Dr Brona Murphy

Dr Brona Murphy

Senior Council Member

 

Dr Brona Murphy is a senior lecturer in the Department of Physiology & Medical Physics and principal investigator within the Centre for Systems Medicine in the same department. She received her B.Sc. in Biotechnology from NUI, Galway in 2000.

She then studied in Trinity College Dublin under the supervision of Prof Seamus Martin and received her PhD in 2004. Her thesis research examined apoptosis-associated caspase activation events. Upon moving to the RCSI, she was awarded a Post-Doctoral Research Fellowship from the Health Research Board to study the regulation of apoptotic pathways in the epileptic brain. Her research was conducted between laboratories in the RCSI and the Dow Neurobiology Lab, Legacy Research Centre, Portland, Oregon, USA.

Upon her return to Ireland, Dr Murphy was awarded a Stokes Lectureship from Science Foundation Ireland and began working as an independent PI. The focus of Dr Murphy’s research is to gain a better understanding of how brain tumours resist cell death upon treatment. Her group examines cell death pathways at the molecular level, in both adult and paediatric brain tumours, with the overall aim of increasing the susceptibility of these tumours to death. Dr Murphy hopes that by elucidating and targeting cell death pathways in these tumours, current and future therapies will be more effective, and ultimately patient survival will improve.

Her group’s research is funded by grants from the RCSI, HRB, SFI, H2020 Framework Programme and the NCRC.

Link to RCSI

3D mammosphere culture of breast epithelial cell line MCF10A.

Courtesy of Dr. Emer Bourke, NUI Galway.

Phospho-Akt expression and localisation

Mediated by VEGF in A549 lung cancer cells
Visualised by high content image analysis.

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

Metaphase chromosome spread of Jurkat T-lymphoma cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD  

Apoptosis assessment of SKMES-1 lung cancer cells

Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

HeLa Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

55th Annual Conference 2019

20 — 22 February 2019 at Europa Hotel, Belfast

Mitotic Chronic Myelogenous Leukaemia K562 Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Cell to Cell Tweeting

Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC) 

Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.

Confocal microscopy analysis

Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

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Education Grants

The Irish Association for Cancer Research will support a limited number of Educational Grants that
will be made available to postgraduate PhD researchers who have been affected by the Covid-19
pandemic. We acknowledge that many of our members have been significantly impacted by the
recent pandemic that may have affected their ability to continue and/or complete research projects.

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