Dr Andrew Lindsay

Independent investigator in the School of Biochemistry and Cell Biology, UCC.

Dr Andrew Lindsay is a graduate of Trinity College Dublin and obtained a PhD from University College Cork. He has previously worked in the Department of Medical and Molecular Genetics in the Indiana University School of Medicine and at the Institut Curie, Paris. He is currently an independent investigator in the School of Biochemistry and Cell Biology, UCC.

His group studies the endosomal recycling pathway, and the role that its dysregulation plays in the aggressiveness of certain cancers. This pathway is the main cellular mechanism for controlling the composition of the plasma membrane. Research from his lab has shown that inhibiting endosomal recycling reduces the metastatic potential of cancer cells, and can also enhance the effectiveness of a number of targeted therapies.

Dr Lindsay has received a number of grants including a HRB Career Development Award and a Marie Curie Research Fellowship. The main focus of his laboratory is to identify and characterise small-molecule inhibitors of the endosomal recycling pathway that may be useful as novel anti-cancer therapies.

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Andrew's Institute Profile

3D mammosphere culture of breast epithelial cell line MCF10A.

Courtesy of Dr. Emer Bourke, NUI Galway

Phospho-Akt expression and localisation

Mediated by VEGF in A549 lung cancer cells. Visualised by high content image analysis.

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

Metaphase chromosome spread of Jurkat T-lymphoma cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Apoptosis assessment of SKMES-1 lung cancer cells

Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

HeLa Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

IACR & EACR Joint Conference 2020

26 — 28 February 2020 at Galway Bay Hotel, Galway

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Mitotic Chronic Myelogenous Leukaemia K562 Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Cell to Cell Tweeting

Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC)

Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.

Confocal Microscopy Analysis

Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

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Virtual IACR Cancer Conference

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Education Grant 2020

The Irish Association for Cancer Research supported five Educational Grants in 2020. These were made available to postgraduate PhD researchers who had been affected by the Covid-19  pandemic.

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Irish Association
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