Prof. Amanda McCann

Prof. Amanda McCann

President

Prof. Amanda McCann PhD, is a PI and UCD Senior Conway Fellow in the UCD Conway Institute of Biomolecular and Biomedical Science University College Dublin (UCD), Ireland, and was Head of Pathology within the UCD School of Medicine from 2015-2018.

Her group’s specific cancer research interests are focused on understanding the mechanisms underlying chemoresistance for women presenting with triple negative breast cancer (TNBC).  In this regard, she has published extensively in the area of cancer cell senescence and the role of extracellular vesicles/exosomes in the chemoresistant phenotype. She was also a member of the founding committee in the establishment of the International Cellular Senescence Association (ICSA).

In 2017, she became Director of the UCD Centre in Translational Oncology (UCTO) with an official launch in September 2018. In 2016 she established and currently chairs the UCD Patient Voice in Cancer Research (PVCR) Committee; a committee striving to engage the general public and cancer survivors in cancer research ensuring a two-way dialogue between patients and researchers.

Within UCD she sits on an expert panel for the Rapid Realist Review (RRR) detailing the mechanisms that enable the reciprocal involvement of seldom heard groups in health and social care funded through the HRB Ignite award, where UCD in collaboration with 10 partner organisations is developing a PPI network and resource platform to firmly embed patient and public involvement in UCD’s research learning and teaching activities.

In relation to patient advocate groups, she previously was a Co-Director of IPPOSI and research adviser to Debra Ireland.

In 2017, she was elected President of the Irish Association for Cancer Research (IACR) and has led on patient involvement with cancer researchers across Ireland as part of the annual IACR conferences.

As President of the IACR she represents the association on the European Association for Cancer Research (EACR) National Societies Committee and was previously Honorary Secretary of the IACR 1998-2000.

3D mammosphere culture of breast epithelial cell line MCF10A.

Courtesy of Dr. Emer Bourke, NUI Galway

Phospho-Akt expression and localisation

Mediated by VEGF in A549 lung cancer cells. Visualised by high content image analysis.

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

Metaphase chromosome spread of Jurkat T-lymphoma cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Apoptosis assessment of SKMES-1 lung cancer cells

Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

HeLa Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

IACR & EACR Joint Conference 2020

26 — 28 February 2020 at Galway Bay Hotel, Galway

Mitotic Chronic Myelogenous Leukaemia K562 Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Cell to Cell Tweeting

Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC)

Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.

Confocal Microscopy Analysis

Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

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Virtual IACR Cancer Conference

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Education Grant 2020

The Irish Association for Cancer Research supported five Educational Grants in 2020. These were made available to postgraduate PhD researchers who had been affected by the Covid-19
 pandemic. 

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