Dr Aileen Houston

Dr Aileen Houston

Senior Council Member

 

Dr. Aileen Houston is a Senior Research Scientist in the Department of Medicine, University College Cork (UCC) and a Faculty Member of the Alimentary Pharmabiotic Centre (APC) Research Institute, UCC. She has a B.Sc. in Biomedical Science and a Ph.D. in Medicine from UCC. Her thesis research investigated the role of death receptors in colon carcinogenesis.

In 2005, she was awarded a post-doctoral fellowship from the Health Research Board of Ireland to investigate the molecular mechanisms regulating the expression of apoptotic death receptors in colon cancer, and was awarded in 2006 the St. Luke’s Young Investigator Award from the Royal Academy of Medicine in Ireland.

Dr. Houston’s research is focused on the role of inflammation in cancer, in particular on the role of tumour-derived and stromal-derived inflammatory factors in tumour development and the anti-tumour immune response. Her research is currently focused on elucidating the role of members of the death receptor family in tumour development and progression. While these death receptors are known to be capable of inducing the apoptotic cell death of cancer cells, she is particularly interested in the non-apoptotic functions of these receptors in tumorigenesis.

Other areas of interest include understanding the role of inflammatory members of the interleukin-1 family in tumorigenesis. The ultimate aim of her research is to identify potential targets for the development of anti-inflammatory reagents and anti-cancer therapies. Research in her laboratory is currently funded by Science Foundation Ireland.

3D mammosphere culture of breast epithelial cell line MCF10A.

Courtesy of Dr. Emer Bourke, NUI Galway

Phospho-Akt expression and localisation

Mediated by VEGF in A549 lung cancer cells. Visualised by high content image analysis.

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

Metaphase chromosome spread of Jurkat T-lymphoma cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Apoptosis assessment of SKMES-1 lung cancer cells

Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

HeLa Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

IACR & EACR Joint Conference 2020

26 — 28 February 2020 at Galway Bay Hotel, Galway

Mitotic Chronic Myelogenous Leukaemia K562 Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Cell to Cell Tweeting

Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC)

Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.

Confocal Microscopy Analysis

Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

IACR Membership

We have a number of membership categories available. Find out which membership suits you.

Virtual IACR Cancer Conference

The virtual IACR Annual Meeting takes place 24th - 26th March 2021.

IACR Public Engagement

Would you like to know more about how we involve patients in research, our fundraising, and lay seminars?

Latest News

Education Grant 2020

The Irish Association for Cancer Research supported five Educational Grants in 2020. These were made available to postgraduate PhD researchers who had been affected by the Covid-19
 pandemic. 

FACEBOOK

Irish Association
for Cancer Research  

9A Coolkill, Sandyford
Dublin 18, Ireland
D18 C1W3

info@iacr.ie
+353 (0)295 8859

Irish Association for Cancer Research (IACR) is a registered charity on the Register of Charitable Organisations, Charities Regulator, 3 George's Dock, IFSC, Dublin 1, D01 X5X0, Ireland.

Registered Charity Number (RCN): 20030117.

©Design by LetterEleven