Denis Collins

Denis Collins

Junior Council Member

 

Denis Collins is a translational research scientist and Principal Investigator in Cancer Biotherapeutics with Prof. John Crown’s Molecular Therapeutics for Cancer group based at the NICB, Dublin City University. Denis has a degree in Biochemistry from University College Cork. He graduated from DCU with his PhD on drug resistance in lung cancer in 2008.

Denis’s current work is examining the white blood cell response to antibody therapies like Herceptin and Perjeta in breast cancers that express the HER2 protein. He is looking for the combination of antibody therapy and the less expensive TKIs (tyrosine kinase inhibitors e.g. Tyverb) that will result in the best anti-cancer immune response in breast cancer patients.

The experiments he conducts use cancer cells grown in the laboratory and samples from patients (tumour biopsies, white blood cells, and plasma) receiving chemotherapy. His work aims to improve breast cancer patient outcomes, provide health economic benefits and find evidence for further new treatment strategies employing a new class of therapy, immune checkpoint inhibitors.

Current members of his group include Nicola Gaynor whose PhD studies focus on the rationale for using immune checkpoint inhibitors in breast cancer and Dr. Neil Conlon who is working on re-purposing already approved therapies for use in treatment-resistance cancers. The aim of Cancer Biotherapeutics is to get novel treatment strategies to clinical trial.

Denis has been awarded an Irish Research Council Enterprise Partnership Scheme Postdoctoral Fellowship and a Roche Postdoctoral Fellowship. His research team is funded by the Cancer Clinical Research Trust and an industry/academia collaboration with Puma Biotechnology. He is currently Chair of the Junior Council of the Irish Association for Cancer Research.

3D mammosphere culture of breast epithelial cell line MCF10A.

Courtesy of Dr. Emer Bourke, NUI Galway

Phospho-Akt expression and localisation

Mediated by VEGF in A549 lung cancer cells. Visualised by high content image analysis.

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

Metaphase chromosome spread of Jurkat T-lymphoma cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Apoptosis assessment of SKMES-1 lung cancer cells

Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

HeLa Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

IACR & EACR Joint Conference 2020

26 — 28 February 2020 at Galway Bay Hotel, Galway

Mitotic Chronic Myelogenous Leukaemia K562 Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Cell to Cell Tweeting

Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC)

Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.

Confocal Microscopy Analysis

Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

IACR Membership

We have a number of membership categories available. Find out which membership suits you.

IACR Conference

Due to COVID restrictions we have yet to confirm the dates for 57th Annual Conference. 

Please check back here later in 2020 to check for updates. 

IACR Public Engagement

Would you like to know more about how we involve patients in research, our fundraising, and lay seminars?

Latest News

Education Grants

The Irish Association for Cancer Research will support a limited number of Educational Grants that
will be made available to postgraduate PhD researchers who have been affected by the Covid-19
pandemic. We acknowledge that many of our members have been significantly impacted by the
recent pandemic that may have affected their ability to continue and/or complete research projects.

FACEBOOK

Irish Association
for Cancer Research  

9A Coolkill, Sandyford
Dublin 18, Ireland
D18 C1W3

info@iacr.ie
+353 (0)295 8859

Irish Association for Cancer Research (IACR) is a registered charity on the Register of Charitable Organisations, Charities Regulator, 3 George's Dock, IFSC, Dublin 1, D01 X5X0, Ireland.

Registered Charity Number (RCN): 20030117.

©Design by LetterEleven