Denis Collins

Denis Collins

Junior Council Member

 

Denis Collins is a translational research scientist and Principal Investigator of the Cancer Biotherapeutics group based at the NICB, Dublin City University.

The ultimate aim of Cancer Biotherapeutics group is to improve patient outcomes by getting novel treatment strategies to clinical trial.

Denis has a degree in Biochemistry from University College Cork. He graduated from DCU with his PhD on drug resistance in lung cancer in 2008. Since then, Denis has been awarded an Irish Research Council Enterprise Partnership Scheme Postdoctoral Fellowship and a Roche Postdoctoral Fellowship to support his research. He is a past Chair of the Junior Council of the Irish Association for Cancer Research (IACR) and is presently a member of the IACR Senior Council.

Denis is currently The Caroline Foundation Senior Research Fellow and Co-PI on a Science Foundation Ireland Strategic Partnership Programme Award, ACORN, that is studying the potential of small molecule tyrosine kinase inhibitors as treatments in multiple cancer types including breast, lung, gastric, oesophageal and skin cancer.

His research team is also funded by the Cancer Clinical Research Trust and the Irish Research Council. These studies investigate new antibody drug conjugate combinations and the immune response mediated by NK cells and monoclonal antibody therapies in breast cancer. Immune-based biomarker studies using patient blood and tumour are underway in lung, breast, gastric/oesophageal and skin cancers. 

3D mammosphere culture of breast epithelial cell line MCF10A.

Courtesy of Dr. Emer Bourke, NUI Galway

Phospho-Akt expression and localisation

Mediated by VEGF in A549 lung cancer cells. Visualised by high content image analysis.

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

Metaphase chromosome spread of Jurkat T-lymphoma cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Apoptosis assessment of SKMES-1 lung cancer cells

Using a multiparameter apoptosis staining kit, showing cell nuclei (blue), actin (green) and mitochondrial activity (orange).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

HeLa Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

IACR & EACR Joint Conference 2020

26 — 28 February 2020 at Galway Bay Hotel, Galway

Mitotic Chronic Myelogenous Leukaemia K562 Cells

Courtesy of Rebecca Gorry, PhD Student, Mc Gee Lab, UCD School of Biomolecular & Biomedical Science, Conway Institute, UCD

Cell to Cell Tweeting

Via nanoparticles (red) in Triple Negative Breast Cancer (TNBC)

Courtesy of Sinéad Lindsay, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD) Ireland.

Confocal Microscopy Analysis

Of phospho-Akt expression in H460 lung cancer cells in response to hypoxia (0.5% O2).

Courtesy of Dr Martin Barr, Clinical Scientist & Adjunct Assistant Professor, St James’s Hospital & Trinity College Dublin

EACR Free Membership

The IACR is an affiliated national society and its members benefit from full membership of the EACR.

Save The Date

IACR 2023 Conference
Venue: Athlone Radisson Blu Hotel
Dates:
Wed 22/02/2023 – Fri 24/02/2023

Please check back later in the year for more information.

IACR in the Irish Independent

We supported the Cancer 2022 Campaign from @Mediaplanet

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